Metformin Use May Not Improve Pancreatic Cancer Survival 4/21/2015 PHILADELPHIA ? Metformin use did not improve survival of patients with pancreatic ductal adenocarcinoma (PDAC) in a retrospective cohort study, according to data presented here at the AACR Annual Meeting 2015, April 18-22. Roongruedee Chaiteerakij, MD, PhD
“The diabetes drug metformin is being used in some cancer treatment trials based on epidemiologic studies that have reported that use of metformin reduces the risk of death from cancer,” said Roongruedee Chaiteerakij, MD, PhD, of the Division of Gastroenterology and Hepatology at Mayo Clinic Cancer Center in Rochester, Minnesota. “This study highlights the importance of appropriate design of retrospective studies and the necessity of conducting prospective studies with solid rationale for determining the effect of diabetes drugs on cancer risk or death.”
According to Chaiteerakij, several epidemiological studies based on retrospective data have reported that metformin is associated with longer survival from different cancers, including pancreatic cancer. Cancer clinical trials have been opened that incorporate metformin in a treatment arm, in part based on these studies, but whether metformin has a beneficial effect on improving survival of cancer patients remains unproven.
In this retrospective study to comprehensively assess metformin use and survival, Chaiteerakij and colleagues used data from 1,360 patients with PDAC who had data available from the Mayo Clinic Specialized Programs of Research Excellence (SPORE) in pancreatic cancer database. Patients were categorized by metformin use into five groups depending on when they used metformin, from those who had never used metformin to those who started taking metformin more than 30 days after PDAC diagnosis. 0268がんと闘う名無しさん2015/05/09(土) 00:22:10.45ID:4MQtLBjq>>267 岡山大とは違う結果ということ? 0269がんと闘う名無しさん2015/05/09(土) 01:44:57.05ID:LROX605G アルコール膵炎で3回入院したけど焼酎は毎晩飲んでるよ、但し日本酒はダメ、膵炎しますよ! 0270がんと闘う名無しさん2015/05/09(土) 16:31:45.24ID:nKCCFN2i みんなかっこよすぎるわ。 0271がんと闘う名無しさん2015/06/26(金) 17:15:43.96ID:cNTfPxXJ>>268 メトフォルミンなんて生易しいクスリでどうかなるほど膵がんは甘くはないいうこっちゃ 0272がんと闘う名無しさん2015/10/13(火) 15:55:07.54ID:vGLZqK8Khttp://cancerpreventionresearch.aacrjournals.org/content/early/2015/09/09/1940-6207.CAPR-15-0141.short?rss=1
Metformin Use and Risk of Prostate Cancer: Results from the REDUCE Study